S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Identifieur interne : 000177 ( France/Analysis ); précédent : 000176; suivant : 000178S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship
Auteurs : Alexis Elbaz [France] ; Clotilde Levecque [France] ; Jacqueline Clavel [France] ; Jean-Sébastien Vidal [France] ; Florence Richard [France] ; Jean-René Corrèze [France] ; Bernard Delemotte [France] ; Philippe Amouyel [France] ; Annick Alpérovitch [France] ; Marie-Christine Chartier-Harlin [France] ; Christophe Tzourio [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-02.
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Abstract
We studied the relationship between Parkinson's disease (PD) and the S18Y polymorphism in the UCH‐L1 gene and the effect on this relationship of age at onset, smoking, and pesticides. Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10326
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Patients requested free health coverage for PD to the Mutualité Sociale Agricole (MSA), the French health insurance organization for people whose work is related to agriculture. Controls requested reimbursement of health expenses to the MSA. A maximum of three controls were matched to each case. Analyses included participants with both parents born in Europe. There were no differences in S18Y genotypes between patients (n = 209; 67% SS, 32% SY, 1% YY) and controls (n = 488; 66% SS, 30% SY, 4% YY). The relationship between PD and S18Y was modified by age at onset (P = 0.03). The Y allele was inversely associated with PD for patients with onset before 61 years (odds ratio [OR] = 0.53; 95% confidence interval [CI], 0.29–0.99); there was no association for older patients (62–68 years: OR = 1.21; 95% CI, 0.67–2.20; >68 years: OR = 1.24; 95% CI, 0.67–2.31). Among patients, Y carriers had a later onset than noncarriers (P = 0.04). These findings were not modified or confounded by smoking and pesticides. In this community‐based case‐control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Lille</li><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></noRegion><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><name sortKey="Correze, Jean Ene" sort="Correze, Jean Ene" uniqKey="Correze J" first="Jean-René" last="Corrèze">Jean-René Corrèze</name><name sortKey="Delemotte, Bernard" sort="Delemotte, Bernard" uniqKey="Delemotte B" first="Bernard" last="Delemotte">Bernard Delemotte</name><name sortKey="Levecque, Clotilde" sort="Levecque, Clotilde" uniqKey="Levecque C" first="Clotilde" last="Levecque">Clotilde Levecque</name><name sortKey="Richard, Florence" sort="Richard, Florence" uniqKey="Richard F" first="Florence" last="Richard">Florence Richard</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Vidal, Jean Ebastien" sort="Vidal, Jean Ebastien" uniqKey="Vidal J" first="Jean-Sébastien" last="Vidal">Jean-Sébastien Vidal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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